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Molecular Dynamics Simulation of a potassium channel in interaction with TRX2 potassium channel opening property – © Oxford Biolabs Ltd.

The recent discovery that potassium ion channels exist within the dermal papilla cells of human hair follicles provided a novel therapeutic target for researchers. Potassium ion channels have been implicated in a vast array of diseases ranging from Hepatitis C to Diabetes. These small pore-forming protein structures control the transport of potassium ions across the hair follicle’s cell membranes and are essential for maintaining the follicle’s full biological activity and function.

Scientists have demonstrated that as people experience hair loss the function of potassium channels within hair follicles diminishes. The effect is impaired membrane potential and interrupted ion transportation across the hair follicle’s cellular membranes – resulting in shrinking follicles and thinning hair.

Based on this research, TRX2 devised an elegant solution for stimulating hair growth on a molecular level: The rejuvenation of potassium ion channels within hair follicles.*

TRX2® Molecular Hair Growth Supplement consists of natural substances that our body normally manufactures at sufficient levels in healthy hair, but at insufficient quantities as we experience hair loss. TRX2® Molecular Hair Growth Supplement is a patent-pending composition of normal metabolites that has been shown in laboratory experiments to help reduce hair loss and promote healthy hair growth by:

1. Maintaining the membrane potential of hair follicles*
2. Stimulating the de novo synthesis of potassium channels*
3. Restoring potassium channel activity & functionality*
4. Hyperpolarizing hair follicles*

TRX2® promotes the hair follicles health and growth on a molecular level*

Boosting Energy Levels in Hair Follicles*

In 2007 Foitzik et al. demonstrated that L-carnitine-L-tartrate promotes human hair growth; suggesting that L-carnitine stimulates scalp hair growth by up regulation of proliferation and down-regulation of apoptosis in follicular cells. TRX2® products are the first to use Potassium and L-carnitine-L-tartrate as part of their active ingredients for treating hair loss.
Research shows that L-carnitine-L-tartrate stimulates hair growth by increasing the energy supply to the massively proliferating and insatiable anagen hair matrix – energy that is also required for the full biological activity of potassium channels in hair follicles.

Maintaining The Cell Membrane Potential of Hair Follicles*

The membrane potential is the result of differing voltage between the inner and outer surfaces of a cell’s membrane. This process requires energy-driven potassium channels to move charge against a gradient. The dermal papilla cells of a healthy hair follicle (one containing sufficient potassium channels) have maximum membrane potential, sustaining the highest level of biological activity. However, as we experience hair loss, the membrane potential of these dermal papilla cells is diminished – a result of the impaired functionality of potassium channels within the hair follicle.

TRX2® contains a compound that stimulates the synthesis of cardiolipin, a key component of the plasma membrane of dermal papilla cells in hair follicles. Cardiolipin plays a crucial role in maintaining the potential and integrity of hair follicle cell membranes. In short, TRX2® provides theideal lipid environment for potassium channels to flourish and function at peak efficiency.

Stimulating de novo Synthesis of Potassium Channels in Hair Follicles*

The specific potassium channel found in human hair follicles has three major amino acid components: L-Leucine, Isoleucine and Valine (often referred to as BCAA).
By incorporating these components into our proprietary complex, our team has successfully found a way to replenish the membrane potential of hair cells and stimulate the synthesis of new potassium channels within hair follicles.

Stimulating Potassium Channel Activity & Functionality*

Physiologically, the potassium channels of hair follicles are regulated by intracellular levels of nucleotides (e.g., ATP and ADP). Therefore, the electrical activity of a cell’s membrane is linked to its metabolism; a relationship that controls many diverse cellular functions.
The TRX2® composition contains several sources of ATP. TRX2® activates the transport of high-energy, food-derived products into the body’s mitochondria, where they are ultimately converted into ATP. This captured energy revitalizes potassium channels and is necessary for the regulation of ion transport across the cellular membranes.

Promotion of Hair Growth by Hyperpolarizing Hair Follicles*

The TRX2® complex, similar to the FDA approved treatment minoxidil (Rogaine™, Regaine™ or RIUP™), has several properties of known potassium channel openers. By hyperpolarizing the hair follicle’s plasma membranes, TRX2® increases the size of shrunken follicles – resulting in longer, thicker and significantly more hair over the course of treatment.
The proprietary composition contains a natural compound, nicotinic acid, which is structurally related to minoxidil. In combination with the other TRX2® compounds, nicotinic acid helps keep potassium channels open over time and supports the growth of healthy follicles.

Minoxidil – a known potassium channel opener
Topically applied minoxidil is one of the most widely used treatment options against male and female pattern hair loss. However, being a highly potent drug, minoxidil has well documented side-effects and measurable changes disappear within months after discontinuation of treatment (read more). Originally minoxidil was developed as an oral antihypertensive drug, but a frequent side-effect was hair growth. The detailed mechanism of action of minoxidil on hair follicles is unclear. However, known as a potent potassium channel opener, it can be assumed that the drug targets the same tiny protein structures (potassium channels) TRX2® does.
Compared to minoxidil TRX2® is a 100% natural, drug-free food supplement designed to provide hair follicles with the specific compounds needed to promote healthy, natural hair growth. There are no side-effects, no complications and no hassle – just honest, noticeable results.

The bio-active compounds of
TRX2® are embedded in a
proprietary potassium
channel-stimulating
complex and
delivered via the
blood stream
to the hair
follicle for
maximum
benefit.
Uncovering the right formula of natural ingredients was a massive undertaking. Our dedicated team of scientists needed to design a variety of new research methods specifically for the purpose of targeting potassium ion channels for hair growth. After trying hundreds of different formulations of micro-nutrients, we centered upon the TRX2® formula that includes a plethora of unique and powerful ingredients. This approach has allowed our company to succeed where others have failed. Our product works with your body to protect hair cells from damage and degradation.
Listed below are some of the specific beneficial effects observed at the cellular level:

Cellular level

  1. Increased membrane potential of dermal papilla cells in hair follicles*
  2. De novo synthesis of potassium channels*
  3. Enhanced potassium channel activity & functionality*
  4. Hyperpolarized hair follicles*

This product is specifically designed for customers suffering from the early stages of hair loss (Norwood 1-4). Some of the benefits reported by those who regularly take three TRX2® Molecular Hair Growth Supplement capsules per day include:

Visual level

  • The cessation of hair loss*
  • The promotion of hair growth – including frontal region and temple area*
  • Visibly stronger & thicker hair shafts*
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* These statements have not been evaluated by the medicines regulatory agencies. This product is not a drug or medicine, and is not intended to diagnose, treat, cure or prevent any disease. This patent-pending food supplement contains nutrients that help maintain normal healthy hair. Zinc, selenium and biotin contribute to the maintenance of normal hair. Normal hair is also characterised by healthy hair growth and non-excessive hair loss. Results may vary and are subject to your individual metabolism. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product. Regarding risks and side-effects please see the package insert and ask your physician or healthcare specialist. Read full disclaimer. Read Legal Notices.

Disclaimer: The entire contents of this website are based upon the opinions and research of Oxford Biolabs Ltd., unless otherwise noted. Individual articles are based upon the opinions of the respective author, who may retain copyright as marked. Statements related to the rejuvenation, activation and stimulation of potassium channels are not intended to promote any specific ingredient, regimen, or use and should not be construed as evidence of the safety, effectiveness, or intended uses of the TRX2® product. It is purely presented as information about Oxford Biolabs's research focus and rationality behind formulating the TRX2 food supplement. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Oxford Biolabs Ltd. and its community. Oxford Biolabs Ltd. encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. See our terms of service and privacy policy and full disclaimer here